diff --git a/.changeset/wise-mugs-sell.md b/.changeset/wise-mugs-sell.md
new file mode 100644
index 0000000000..35b333ba75
--- /dev/null
+++ b/.changeset/wise-mugs-sell.md
@@ -0,0 +1,5 @@
+---
+'@backstage/plugin-catalog': patch
+---
+
+Display warning when Entity has orphan annotation.
diff --git a/packages/app/src/components/catalog/EntityPage.tsx b/packages/app/src/components/catalog/EntityPage.tsx
index c1d892e061..f646992c97 100644
--- a/packages/app/src/components/catalog/EntityPage.tsx
+++ b/packages/app/src/components/catalog/EntityPage.tsx
@@ -40,6 +40,8 @@ import {
   isComponentType,
   isKind,
   EntityHasResourcesCard,
+  EntityOrphanWarning,
+  isOrphan,
 } from '@backstage/plugin-catalog';
 import {
   EntityCircleCIContent,
@@ -214,7 +216,15 @@ const errorsContent = (
 
 const overviewContent = (
   <Grid container spacing={3} alignItems="stretch">
-    <Grid item md={6}>
+    <EntitySwitch>
+      <EntitySwitch.Case if={isOrphan}>
+        <Grid item xs={12}>
+          <EntityOrphanWarning />
+        </Grid>
+      </EntitySwitch.Case>
+    </EntitySwitch>
+
+    <Grid item md={8} xs={12}>
       <EntityAboutCard variant="gridItem" />
     </Grid>
 
@@ -226,7 +236,7 @@ const overviewContent = (
       </EntitySwitch.Case>
     </EntitySwitch>
 
-    <Grid item md={4} sm={6}>
+    <Grid item md={4} xs={12}>
       <EntityLinksCard />
     </Grid>
 
@@ -260,7 +270,7 @@ const overviewContent = (
       </EntitySwitch.Case>
     </EntitySwitch>
 
-    <Grid item md={6}>
+    <Grid item md={8} xs={12}>
       <EntityHasSubcomponentsCard variant="gridItem" />
     </Grid>
   </Grid>
diff --git a/plugins/catalog/src/components/EntityOrphanWarning/DeleteEntityDialog.test.tsx b/plugins/catalog/src/components/EntityOrphanWarning/DeleteEntityDialog.test.tsx
new file mode 100644
index 0000000000..d9f266cce7
--- /dev/null
+++ b/plugins/catalog/src/components/EntityOrphanWarning/DeleteEntityDialog.test.tsx
@@ -0,0 +1,132 @@
+/*
+ * Copyright 2021 Spotify AB
+ *
+ * Licensed under the Apache License, Version 2.0 (the "License");
+ * you may not use this file except in compliance with the License.
+ * You may obtain a copy of the License at
+ *
+ *     http://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+import userEvent from '@testing-library/user-event';
+import React from 'react';
+import { DeleteEntityDialog } from './DeleteEntityDialog';
+import { ORIGIN_LOCATION_ANNOTATION } from '@backstage/catalog-model';
+import {
+  AlertApi,
+  alertApiRef,
+  ApiProvider,
+  ApiRegistry,
+} from '@backstage/core';
+import { CatalogApi } from '@backstage/catalog-client';
+import { catalogApiRef } from '@backstage/plugin-catalog-react';
+import { screen, waitFor } from '@testing-library/react';
+import { renderInTestApp } from '@backstage/test-utils';
+
+describe('DeleteEntityDialog', () => {
+  const alertApi: jest.Mocked<AlertApi> = {
+    post: jest.fn(),
+    alert$: jest.fn(),
+  };
+
+  const catalogClient: jest.Mocked<CatalogApi> = {
+    removeEntityByUid: jest.fn(),
+  } as any;
+  const apis = ApiRegistry.with(catalogApiRef, catalogClient).with(
+    alertApiRef,
+    alertApi,
+  );
+
+  const entity = {
+    apiVersion: 'backstage.io/v1alpha1',
+    kind: 'Component',
+    metadata: {
+      uid: '123',
+      name: 'n',
+      namespace: 'ns',
+      annotations: {
+        [ORIGIN_LOCATION_ANNOTATION]: 'url:http://example.com',
+      },
+    },
+    spec: {},
+  };
+
+  const Wrapper = ({ children }: { children?: React.ReactNode }) => (
+    <ApiProvider apis={apis}>{children}</ApiProvider>
+  );
+
+  afterEach(() => {
+    jest.resetAllMocks();
+  });
+
+  it('can cancel', async () => {
+    const onClose = jest.fn();
+
+    await renderInTestApp(
+      <Wrapper>
+        <DeleteEntityDialog
+          open
+          onClose={onClose}
+          onConfirm={() => {}}
+          entity={entity}
+        />
+      </Wrapper>,
+    );
+
+    userEvent.click(screen.getByText('Cancel'));
+
+    await waitFor(() => {
+      expect(onClose).toBeCalled();
+    });
+  });
+
+  it('can delete', async () => {
+    const onConfirm = jest.fn();
+
+    await renderInTestApp(
+      <Wrapper>
+        <DeleteEntityDialog
+          open
+          onClose={() => {}}
+          onConfirm={onConfirm}
+          entity={entity}
+        />
+      </Wrapper>,
+    );
+
+    userEvent.click(screen.getByText('Delete'));
+
+    await waitFor(() => {
+      expect(catalogClient.removeEntityByUid).toBeCalledWith('123');
+      expect(onConfirm).toBeCalled();
+    });
+  });
+
+  it('handles error', async () => {
+    const onConfirm = jest.fn();
+
+    await renderInTestApp(
+      <Wrapper>
+        <DeleteEntityDialog
+          open
+          onClose={() => {}}
+          onConfirm={onConfirm}
+          entity={entity}
+        />
+      </Wrapper>,
+    );
+
+    catalogClient.removeEntityByUid.mockRejectedValue(new Error('no no no'));
+    userEvent.click(screen.getByText('Delete'));
+
+    await waitFor(() => {
+      expect(catalogClient.removeEntityByUid).toBeCalledWith('123');
+      expect(alertApi.post).toBeCalledWith({ message: 'no no no' });
+    });
+  });
+});
diff --git a/plugins/catalog/src/components/EntityOrphanWarning/DeleteEntityDialog.tsx b/plugins/catalog/src/components/EntityOrphanWarning/DeleteEntityDialog.tsx
new file mode 100644
index 0000000000..26b6b29650
--- /dev/null
+++ b/plugins/catalog/src/components/EntityOrphanWarning/DeleteEntityDialog.tsx
@@ -0,0 +1,73 @@
+/*
+ * Copyright 2021 Spotify AB
+ *
+ * Licensed under the Apache License, Version 2.0 (the "License");
+ * you may not use this file except in compliance with the License.
+ * You may obtain a copy of the License at
+ *
+ *     http://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+import { Entity } from '@backstage/catalog-model';
+import { alertApiRef, useApi } from '@backstage/core';
+import { catalogApiRef } from '@backstage/plugin-catalog-react';
+import { Button, Dialog, DialogActions, DialogTitle } from '@material-ui/core';
+import React, { useState } from 'react';
+
+type Props = {
+  open: boolean;
+  onClose: () => any;
+  onConfirm: () => any;
+  entity: Entity;
+};
+
+export const DeleteEntityDialog = ({
+  open,
+  onClose,
+  onConfirm,
+  entity,
+}: Props) => {
+  const [busy, setBusy] = useState(false);
+  const catalogApi = useApi(catalogApiRef);
+  const alertApi = useApi(alertApiRef);
+
+  const onDelete = async () => {
+    setBusy(true);
+    try {
+      const uid = entity.metadata.uid;
+      await catalogApi.removeEntityByUid(uid!);
+      onConfirm();
+    } catch (err) {
+      alertApi.post({ message: err.message });
+    } finally {
+      setBusy(false);
+    }
+  };
+
+  return (
+    <Dialog open={open} onClose={onClose}>
+      <DialogTitle id="responsive-dialog-title">
+        Are you sure you want to delete this entity?
+      </DialogTitle>
+      <DialogActions>
+        <Button
+          variant="contained"
+          color="secondary"
+          disabled={busy}
+          onClick={onDelete}
+        >
+          Delete
+        </Button>
+        <Button onClick={onClose} color="primary">
+          Cancel
+        </Button>
+      </DialogActions>
+    </Dialog>
+  );
+};
diff --git a/plugins/catalog/src/components/EntityOrphanWarning/EntityOrphanWarning.test.tsx b/plugins/catalog/src/components/EntityOrphanWarning/EntityOrphanWarning.test.tsx
new file mode 100644
index 0000000000..0b3b8de504
--- /dev/null
+++ b/plugins/catalog/src/components/EntityOrphanWarning/EntityOrphanWarning.test.tsx
@@ -0,0 +1,70 @@
+/*
+ * Copyright 2020 Spotify AB
+ *
+ * Licensed under the Apache License, Version 2.0 (the "License");
+ * you may not use this file except in compliance with the License.
+ * You may obtain a copy of the License at
+ *
+ *     http://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+import { ApiProvider, ApiRegistry } from '@backstage/core';
+
+import {
+  CatalogApi,
+  catalogApiRef,
+  catalogRouteRef,
+  EntityProvider,
+} from '@backstage/plugin-catalog-react';
+import { renderInTestApp } from '@backstage/test-utils';
+import React from 'react';
+import { EntityOrphanWarning } from './EntityOrphanWarning';
+
+describe('<EntityOrphanWarning />', () => {
+  const catalogClient: jest.Mocked<CatalogApi> = {
+    removeEntityByUid: jest.fn(),
+  } as any;
+  const apis = ApiRegistry.with(catalogApiRef, catalogClient);
+
+  it('renders EntityOrphanWarning if the entity is orphan', async () => {
+    const entity = {
+      apiVersion: 'v1',
+      kind: 'Component',
+      metadata: {
+        name: 'software',
+        description: 'This is the description',
+        annotations: { 'backstage.io/orphan': 'true' },
+      },
+
+      spec: {
+        owner: 'guest',
+        type: 'service',
+        lifecycle: 'production',
+      },
+    };
+
+    const { getByText } = await renderInTestApp(
+      <ApiProvider apis={apis}>
+        <EntityProvider entity={entity}>
+          <EntityOrphanWarning />
+        </EntityProvider>
+      </ApiProvider>,
+      {
+        mountedRoutes: {
+          '/create': catalogRouteRef,
+        },
+      },
+    );
+    expect(
+      getByText(
+        'This entity is not referenced by any location and is therefore not receiving updates. Click here to delete.',
+      ),
+    ).toBeInTheDocument();
+  });
+});
diff --git a/plugins/catalog/src/components/EntityOrphanWarning/EntityOrphanWarning.tsx b/plugins/catalog/src/components/EntityOrphanWarning/EntityOrphanWarning.tsx
new file mode 100644
index 0000000000..070c36c56c
--- /dev/null
+++ b/plugins/catalog/src/components/EntityOrphanWarning/EntityOrphanWarning.tsx
@@ -0,0 +1,56 @@
+/*
+ * Copyright 2021 Spotify AB
+ *
+ * Licensed under the Apache License, Version 2.0 (the "License");
+ * you may not use this file except in compliance with the License.
+ * You may obtain a copy of the License at
+ *
+ *     http://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+import { Entity } from '@backstage/catalog-model';
+import { useRouteRef } from '@backstage/core';
+import { catalogRouteRef, useEntity } from '@backstage/plugin-catalog-react';
+import { Alert } from '@material-ui/lab';
+import React, { useState } from 'react';
+import { useNavigate } from 'react-router';
+import { DeleteEntityDialog } from './DeleteEntityDialog';
+
+export const isOrphan = (entity: Entity) =>
+  entity?.metadata?.annotations?.['backstage.io/orphan'] === 'true';
+
+/**
+ * Displays a warning alert if the entity is marked as orphan with the ability to delete said entity.
+ */
+export const EntityOrphanWarning = () => {
+  const navigate = useNavigate();
+  const catalogLink = useRouteRef(catalogRouteRef);
+  const [confirmationDialogOpen, setConfirmationDialogOpen] = useState(false);
+  const { entity } = useEntity();
+
+  const cleanUpAfterRemoval = async () => {
+    setConfirmationDialogOpen(false);
+    navigate(catalogLink());
+  };
+
+  return (
+    <>
+      <Alert severity="warning" onClick={() => setConfirmationDialogOpen(true)}>
+        This entity is not referenced by any location and is therefore not
+        receiving updates. Click here to delete.
+      </Alert>
+      <DeleteEntityDialog
+        open={confirmationDialogOpen}
+        entity={entity!}
+        onConfirm={cleanUpAfterRemoval}
+        onClose={() => setConfirmationDialogOpen(false)}
+      />
+    </>
+  );
+};
diff --git a/plugins/catalog/src/components/EntityOrphanWarning/index.ts b/plugins/catalog/src/components/EntityOrphanWarning/index.ts
new file mode 100644
index 0000000000..b64f8c1232
--- /dev/null
+++ b/plugins/catalog/src/components/EntityOrphanWarning/index.ts
@@ -0,0 +1,17 @@
+/*
+ * Copyright 2021 Spotify AB
+ *
+ * Licensed under the Apache License, Version 2.0 (the "License");
+ * you may not use this file except in compliance with the License.
+ * You may obtain a copy of the License at
+ *
+ *     http://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+export { EntityOrphanWarning, isOrphan } from './EntityOrphanWarning';
diff --git a/plugins/catalog/src/index.ts b/plugins/catalog/src/index.ts
index 2e74219718..f7506b534a 100644
--- a/plugins/catalog/src/index.ts
+++ b/plugins/catalog/src/index.ts
@@ -35,3 +35,4 @@ export {
   EntityLinksCard,
   EntitySystemDiagramCard,
 } from './plugin';
+export * from './components/EntityOrphanWarning';