diff --git a/.changeset/shy-carrots-decide.md b/.changeset/shy-carrots-decide.md
new file mode 100644
index 0000000000..5f64f3d4bd
--- /dev/null
+++ b/.changeset/shy-carrots-decide.md
@@ -0,0 +1,5 @@
+---
+'@backstage/plugin-app-backend': patch
+---
+
+Do not force caching of the Javascript asset that contains the injected config.
diff --git a/plugins/app-backend/src/lib/config.ts b/plugins/app-backend/src/lib/config.ts
index 6959253336..05b304075e 100644
--- a/plugins/app-backend/src/lib/config.ts
+++ b/plugins/app-backend/src/lib/config.ts
@@ -31,7 +31,9 @@ type InjectOptions = {
 /**
  * Injects configs into the app bundle, replacing any existing injected config.
  */
-export async function injectConfig(options: InjectOptions) {
+export async function injectConfig(
+  options: InjectOptions,
+): Promise<string | undefined> {
   const { staticDir, logger, appConfigs } = options;
 
   const files = await fs.readdir(staticDir);
@@ -52,7 +54,7 @@ export async function injectConfig(options: InjectOptions) {
         injected,
       );
       await fs.writeFile(path, newContent, 'utf8');
-      return;
+      return path;
     } else if (content.includes('__APP_INJECTED_CONFIG_MARKER__')) {
       logger.info(`Replacing injected env config in ${jsFile}`);
 
@@ -61,10 +63,11 @@ export async function injectConfig(options: InjectOptions) {
         injected,
       );
       await fs.writeFile(path, newContent, 'utf8');
-      return;
+      return path;
     }
   }
   logger.info('Env config not injected');
+  return undefined;
 }
 
 type ReadOptions = {
diff --git a/plugins/app-backend/src/service/router.ts b/plugins/app-backend/src/service/router.ts
index 40e291c19d..158121bb95 100644
--- a/plugins/app-backend/src/service/router.ts
+++ b/plugins/app-backend/src/service/router.ts
@@ -114,6 +114,7 @@ export async function createRouter(
 
   logger.info(`Serving static app content from ${appDistDir}`);
 
+  let injectedConfigPath: string | undefined;
   if (!disableConfigInjection) {
     const appConfigs = await readConfigs({
       config,
@@ -121,7 +122,7 @@ export async function createRouter(
       env: process.env,
     });
 
-    await injectConfig({ appConfigs, logger, staticDir });
+    injectedConfigPath = await injectConfig({ appConfigs, logger, staticDir });
   }
 
   const router = Router();
@@ -132,8 +133,15 @@ export async function createRouter(
   const staticRouter = Router();
   staticRouter.use(
     express.static(resolvePath(appDistDir, 'static'), {
-      setHeaders: res => {
-        res.setHeader('Cache-Control', CACHE_CONTROL_MAX_CACHE);
+      setHeaders: (res, path) => {
+        if (path === injectedConfigPath) {
+          logger.info(
+            `Serving in the injected Javascript file with max caching disabled`,
+          );
+          res.setHeader('Cache-Control', 'no-cache');
+        } else {
+          res.setHeader('Cache-Control', CACHE_CONTROL_MAX_CACHE);
+        }
       },
     }),
   );