diff --git a/.changeset/good-humans-draw.md b/.changeset/good-humans-draw.md
new file mode 100644
index 0000000000..3e97fa15b6
--- /dev/null
+++ b/.changeset/good-humans-draw.md
@@ -0,0 +1,6 @@
+---
+'@backstage/plugin-app-backend': patch
+---
+
+Add a `Cache-Control: no-store, max-age=0` header to the `index.html` response to instruct the browser to not cache the pages.
+This tells the browser to not serve a cached `index.html` that might link to static assets from a previous deployment that are not available anymore.
diff --git a/plugins/app-backend/src/service/router.test.ts b/plugins/app-backend/src/service/router.test.ts
index 35dd9287a6..cabe4c59b9 100644
--- a/plugins/app-backend/src/service/router.test.ts
+++ b/plugins/app-backend/src/service/router.test.ts
@@ -14,11 +14,11 @@
  * limitations under the License.
  */
 
-import { resolve as resolvePath } from 'path';
 import { getVoidLogger } from '@backstage/backend-common';
 import { ConfigReader } from '@backstage/config';
 import express from 'express';
 import Router from 'express-promise-router';
+import { resolve as resolvePath } from 'path';
 import request from 'supertest';
 import { createRouter } from './router';
 
@@ -68,6 +68,22 @@ describe('createRouter', () => {
     expect(response.status).toBe(200);
     expect(response.text.trim()).toBe('this is index.html');
   });
+
+  it.each(['/index.html', '/other.html', '/missing.html'])(
+    'returns %s with no-store Cache-Control header',
+    async file => {
+      const response = await request(app).get(file);
+      expect(response.header['cache-control']).toBe('no-store, max-age=0');
+    },
+  );
+
+  it.each(['/static/main.txt'])(
+    'returns %s with default Cache-Control header',
+    async file => {
+      const response = await request(app).get(file);
+      expect(response.header['cache-control']).toBe('public, max-age=0');
+    },
+  );
 });
 
 describe('createRouter with static fallback handler', () => {
diff --git a/plugins/app-backend/src/service/router.ts b/plugins/app-backend/src/service/router.ts
index 4379fcccb9..8fe8355bc3 100644
--- a/plugins/app-backend/src/service/router.ts
+++ b/plugins/app-backend/src/service/router.ts
@@ -14,14 +14,17 @@
  * limitations under the License.
  */
 
-import { resolve as resolvePath } from 'path';
-import express from 'express';
-import Router from 'express-promise-router';
-import { Logger } from 'winston';
 import { notFoundHandler, resolvePackagePath } from '@backstage/backend-common';
 import { Config } from '@backstage/config';
-import { injectConfig, readConfigs } from '../lib/config';
+import express from 'express';
+import Router from 'express-promise-router';
 import fs from 'fs-extra';
+import { resolve as resolvePath } from 'path';
+import { Logger } from 'winston';
+import { injectConfig, readConfigs } from '../lib/config';
+
+// express uses mime v1 while we only have types for mime v2
+type Mime = { lookup(arg0: string): string };
 
 export interface RouterOptions {
   config: Config;
@@ -95,9 +98,28 @@ export async function createRouter(
   staticRouter.use(notFoundHandler());
 
   router.use('/static', staticRouter);
-  router.use(express.static(appDistDir));
+  router.use(
+    express.static(appDistDir, {
+      setHeaders: (res, path) => {
+        // The Cache-Control header instructs the browser to not cache html files since it might
+        // link to static assets from recently deployed versions.
+        if (
+          ((express.static.mime as unknown) as Mime).lookup(path) ===
+          'text/html'
+        ) {
+          res.setHeader('Cache-Control', 'no-store, max-age=0');
+        }
+      },
+    }),
+  );
   router.get('/*', (_req, res) => {
-    res.sendFile(resolvePath(appDistDir, 'index.html'));
+    res.sendFile(resolvePath(appDistDir, 'index.html'), {
+      headers: {
+        // The Cache-Control header instructs the browser to not cache the index.html since it might
+        // link to static assets from recently deployed versions.
+        'cache-control': 'no-store, max-age=0',
+      },
+    });
   });
 
   return router;