diff --git a/.changeset/young-schools-double.md b/.changeset/young-schools-double.md
new file mode 100644
index 0000000000..8cba2ec8f3
--- /dev/null
+++ b/.changeset/young-schools-double.md
@@ -0,0 +1,5 @@
+---
+'@backstage/plugin-catalog-react': patch
+---
+
+Do not close `Autocomplete` powered multiple-selection filters when checking boxes
diff --git a/plugins/catalog-react/src/components/EntityAutocompletePicker/EntityAutocompletePicker.tsx b/plugins/catalog-react/src/components/EntityAutocompletePicker/EntityAutocompletePicker.tsx
index 09d5a45246..b81d681e6d 100644
--- a/plugins/catalog-react/src/components/EntityAutocompletePicker/EntityAutocompletePicker.tsx
+++ b/plugins/catalog-react/src/components/EntityAutocompletePicker/EntityAutocompletePicker.tsx
@@ -127,6 +127,7 @@ export function EntityAutocompletePicker<
         {label}
         <Autocomplete
           multiple
+          disableCloseOnSelect
           options={availableOptions}
           value={selectedOptions}
           onChange={(_event: object, options: string[]) =>
diff --git a/plugins/catalog-react/src/components/EntityLifecyclePicker/EntityLifecyclePicker.tsx b/plugins/catalog-react/src/components/EntityLifecyclePicker/EntityLifecyclePicker.tsx
index 77925598e1..29002564ca 100644
--- a/plugins/catalog-react/src/components/EntityLifecyclePicker/EntityLifecyclePicker.tsx
+++ b/plugins/catalog-react/src/components/EntityLifecyclePicker/EntityLifecyclePicker.tsx
@@ -105,6 +105,7 @@ export const EntityLifecyclePicker = (props: { initialFilter?: string[] }) => {
         Lifecycle
         <Autocomplete
           multiple
+          disableCloseOnSelect
           options={availableLifecycles}
           value={selectedLifecycles}
           onChange={(_: object, value: string[]) =>
diff --git a/plugins/catalog-react/src/components/EntityOwnerPicker/EntityOwnerPicker.tsx b/plugins/catalog-react/src/components/EntityOwnerPicker/EntityOwnerPicker.tsx
index b067bda0f5..c8a6c64dd6 100644
--- a/plugins/catalog-react/src/components/EntityOwnerPicker/EntityOwnerPicker.tsx
+++ b/plugins/catalog-react/src/components/EntityOwnerPicker/EntityOwnerPicker.tsx
@@ -108,6 +108,7 @@ export const EntityOwnerPicker = () => {
         Owner
         <Autocomplete
           multiple
+          disableCloseOnSelect
           options={availableOwners}
           value={selectedOwners}
           onChange={(_: object, value: string[]) => setSelectedOwners(value)}
diff --git a/plugins/catalog-react/src/components/EntityProcessingStatusPicker/EntityProcessingStatusPicker.tsx b/plugins/catalog-react/src/components/EntityProcessingStatusPicker/EntityProcessingStatusPicker.tsx
index 3fe3b60e25..db48534bc0 100644
--- a/plugins/catalog-react/src/components/EntityProcessingStatusPicker/EntityProcessingStatusPicker.tsx
+++ b/plugins/catalog-react/src/components/EntityProcessingStatusPicker/EntityProcessingStatusPicker.tsx
@@ -74,6 +74,7 @@ export const EntityProcessingStatusPicker = () => {
         Processing Status
         <Autocomplete
           multiple
+          disableCloseOnSelect
           options={availableAdvancedItems}
           value={selectedAdvancedItems}
           onChange={(_: object, value: string[]) => {